Who is at Highest Risk for Complications from Measles Vaccine?
According to the MMRII product insert, persons most at risk for complications from MMRII vaccine include individuals with both primary and acquired immunodeficiency such as AIDS, dysgammaglobulinemic and hypogammaglobulinemic states, and cellular immune deficiencies. Pneumonitis, measles inclusion body encephalitis, and death have also occurred as a result of being inadvertently vaccinated with a measles containing vaccine. 1
Persons with thrombocytopenia or history of the condition may also be at greater risk for exacerbation or redevelopment of thrombocytopenia with subsequent doses of MMRII vaccine.2
Individuals with a personal history of cerebral injury, personal or family history of seizures, or any other health condition where stress related to fever should be avoided, may also be at greater risk for complications.3
As both the live measles and live mumps vaccines are manufactured using chick embryo cell culture, persons with a history of an immediate anaphylactic and anaphylactoid reaction to eggs may be at greater risk of a reaction from the MMRII vaccine. MMRII contains neomycin and persons who have previously experienced an anaphylactic reaction to either systematic or topical neomycin should not be vaccinated with MMRII due to the risk of reaction and subsequent complications resulting from the reaction.4
Merck’s MMR-V (ProQuad) vaccine product insert states that children between 12 and 23 months with no history of vaccination or wild-type infection with measles, mumps, rubella, and varicella have a higher risk of fever and febrile seizure between 5 and 12 days following vaccination with MMR-V in comparison to children who were vaccinated with separate doses of MMRII and Varicella vaccine. Children with a personal or family history of convulsions, a personal history of cerebral illness, or a medical condition where stress from fever should be avoided may also be at a greater risk of complications from MMR-V. 5
Children most at risk for complications from MMR-V vaccine include those with both primary and acquired immunodeficiency such as AIDS, dysgammaglobulinemic and hypogammaglobulinemic states, and cellular immune deficiencies. Pneumonitis, measles inclusion body encephalitis, and death have also occurred as a result of being inadvertently vaccinated with a measles containing vaccine. Reports of disseminated varicella vaccine virus infection in children with underlying immunodeficiency disorders inadvertently with a varicella-containing vaccine have also been documented.6
IMPORTANT NOTE: NVIC encourages you to become fully informed about Measles and the Measles vaccine by reading all sections in the Table of Contents , which contain many links and resources such as the manufacturer product information inserts, and to speak with one or more trusted health care professionals before making a vaccination decision for yourself or your child. This information is for educational purposes only and is not intended as medical advice.
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1 FDA Measles, Mumps and Rubella Virus Vaccine, Live May 16, 2017
5 FDA PROQUAD Product Insert. Jan. 22, 2019