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Who is at highest risk for getting Shingles?

Updated December 17, 2022


shingles

Scientists do not understand the biological mechanisms underlying reactivation of varicella zoster infection, but risk factors are thought to include aging, auto-immune disorders, immunosuppression, and stress.1 2 Other populations at risk for developing shingles are those with weakened immune systems due to HIV/AIDS or other diseases that affect healthy immune function. Drugs used for organ transplants and cancer treatment can also increase the risk of shingles.3 

Individuals who have had the chickenpox can develop shingles and the CDC estimates that in the U.S., one out of three people will develop shingles in their lifetime. The risk of shingles increases after age 50, and half of all people who live to age 85 will have shingles in their lifetime.4

Caucasians are about fifty percent more likely than Blacks to develop shingles and more cases occur in women. In the U.S., it is estimated that a million shingles cases occur annually, with an incidence rate of approximately four cases per 1000 U.S. population each year. Most people who develop shingles will only have one episode, however, it is possible for individuals to develop shingles a second or third time.5

IMPORTANT NOTE: NVIC encourages you to become fully informed about Shingles and the Shingles vaccine by reading all sections in the Table of Contents , which contain many links and resources such as the manufacturer product information inserts, and to speak with one or more trusted health care professionals before making a vaccination decision for yourself or your child. This information is for educational purposes only and is not intended as medical advice.

 


References:

[1] National Institutes of Health Medline Plus. Causes. In: Shingles. Jan. 1, 2020.

[2] Garone S. Understanding What Causes Shingles to Activate. Healthline July 19, 2021.

[3] U.S. Centers for Disease Control and Prevention. Epidemiology In: Shingles (Herpes Zoster) Clinical Overview. Oct. 5, 2020.

[4] U.S. Centers for Disease Control and Prevention. Epidemiology. In: Shingles (Herpes Zoster) Clinical Overview. Oct. 5, 2020.

[5] U.S. Centers for Disease Control and Prevention. Epidemiology. In: Shingles (Herpes Zoster) Clinical Overview. Oct. 5, 2020.

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