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Who should not get Anthrax vaccine?

Updated December 29, 2023


Biothrax Anthrax Vaccine

Biothrax anthrax vaccine is FDA approved for use in persons between 18 and 65 years of age who are at high risk of exposure to anthrax. Persons younger than 18 or older than 65 should not receive Biothrax anthrax vaccine. 

Anyone who has previously experienced an anaphylactic or anaphylactic-like reaction following a previous dose of Biothrax should not receive another dose. The vial stopper of the vaccine contains natural latex and persons with a latex allergy are at an increased risk of an allergic reaction.  

Biothrax anthrax vaccine is a Pregnancy Category D vaccine, which means that there is evidence of harm in human studies or fetal risk has been demonstrated in pre- or post-marketing surveillance data. Pregnant women should not be vaccinated with Biothrax unless the possible benefits of vaccination outweigh the risks. Vaccination of a breastfeeding mother is cautioned as it is not known whether the vaccine is excreted in human milk.  

Biothrax has never been evaluated for safety or efficacy when given with any other licensed vaccine product. 

CYFENDUS Anthrax Vaccine

CYFENDUS anthrax vaccine is FDA approved for use in persons between 18 and 65 years of age with a known or suspected exposure to anthrax, to be given in combination with antibiotics. Persons younger than 18 or older than 65 years should not receive CYFENDUS anthrax vaccine. 

Person who are allergic to any of the ingredients found within CYFENDUS anthrax vaccine or who have previously experienced an allergic reaction to CYFENDUS anthrax vaccine should not receive another dose of the vaccine. 

CYFENDUS anthrax vaccine can cause death to an unborn child. Pregnant women should not receive CYFENDUS anthrax vaccine. Vaccination of a breastfeeding mother is cautioned as it is not known whether the vaccine is excreted in human milk.     

IMPORTANT NOTE: NVIC “Quick Facts” is not a substitute for becoming fully informed about anthrax and the anthrax vaccine. NVIC recommends consumers read comprehensive information NVIC provides on anthrax, the vaccine manufacturer product information inserts, and speak with one or more trusted health care professionals before making a vaccination decision for yourself or your child.


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