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Who is at highest risk for complications from Hepatitis B vaccine?

Updated February 17, 2023

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There is a gap in medical knowledge in terms of doctors being able to predict who will have an adverse reaction to hepatitis B vaccination, and who will not.

Persons at highest risk for complications from hepatitis B vaccine are those with contraindications and/or precautions to the vaccine. These include persons who are allergic to any ingredient found in the vaccine, including a hypersensitivity to yeast. Persons who receive a hepatitis B vaccine while ill may also be at an increased risk of developing complications.1

IMPORTANT NOTE: NVIC encourages you to become fully informed about Hepatitis B and the Hepatitis B vaccine by reading all sections in the Table of Contents , which contain many links and resources such as the manufacturer product information inserts, and to speak with one or more trusted health care professionals before making a vaccination decision for yourself or your child. This information is for educational purposes only and is not intended as medical advice.



[1] U.S. Centers for Disease Control and Prevention. TABLE 4-1. Contraindications and precautions to commonly used vaccines. In: Vaccine Recommendations and Guidelines of the ACIP. Oct. 18, 2022.
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