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Who is at highest risk for complications from Pneumococcal vaccine?

Image source: CDC PHIL

There is a gap in medical knowledge in terms of doctors being able to predict who will have an adverse reaction to pneumococcal vaccination, and who will not.

Children receiving multiple vaccines simultaneously may be more at risk for developing complications as studies have found that children receiving the pneumococcal conjugate vaccine (PCV13) at the same time as the trivalent inactivated influenza vaccine (IIV) were nearly six-times more likely to develop febrile seizures.1 2

Healthy adults receiving a second dose of pneumococcal polysaccharide vaccine (PPSV23) within a few years of a first dose may also be at higher risk of complications as revaccination has been noted to be associated with more frequent and severe localized injection site reactions. 3

IMPORTANT NOTE: NVIC encourages you to become fully informed about Pneumococcal and the Pneumococcal vaccine by reading all sections in the Table of Contents , which contain many links and resources such as the manufacturer product information inserts, and to speak with one or more trusted health care professionals before making a vaccination decision for yourself or your child. This information is for educational purposes only and is not intended as medical advice.

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1 Tse A, Tseng HF, Greene SK, et al Signal identification and evaluation for risk of febrile seizures in children following trivalent inactivated influenza vaccine in the Vaccine Safety Datalink Project, 2010-2011. Vaccine. 2012 Mar 2;30(11):2024-31.

2 Duffy J, Weintraub E, Hambidge SJ, et al. Febrile Seizure Risk After Vaccination in Children 6 to 23 Months. Pediatrics. 2016 Jul;138(1).

3 Jackson LA, Benson P, Sneller VP et al. Safety of revaccination with pneumococcal polysaccharide vaccine. JAMA. 1999 Jan 20;281(3):243-8.

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